Abstract
In this study, a pH/temperature-responsive drug delivery system based on nanodiamonds is successfully developed by grafting nanodiamonds with thermosensitive polymer and then coating with a hyper-branched dendrimer for docetaxel delivery. For this purpose, alyl alchol and poly (N-isopropylacrylamide) was grafted on the surface of nanodiamonds as functional monomer and thermo-sensitive polymer, respectively. Then, three generations of dendrimers were anchored to the grafted polymer chains by using 1, 3-phenylenediamine and methyl acrylate. Chemical bonding, phase analysis, morphology, and thermal behavior were studied by Fourier transform infrared, x-ray diffraction, field emission scanning electron microscopy, and thermogravimetric techniques, respectively. Equilibrium isotherm and kinetic data were fitted well with Langmuir and pseudo-second-order models by giving a maximum capacity of adsorption. The findings of in-vitro release studies shown that the prepared nanocarrier could be employed for docetaxel delivery due to the pH and temperature-dependent sustained release (99.78% after 6 h, at pH = 5.6, T = 45 °C). Using the near-infrared laser irradiation, the docetaxel release reached 90.97% in 20 min, which was about 4.5 folds faster than without laser irradiation. The drug release from nanocarrier was modeled and the Higuchi model was introduced as the best model predicting the release behavior.
Published Version
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