Abstract
We demonstrated enhanced localized surface plasmon resonance (SPR) biosensing based onsubwavelength gold nanoarrays built on a thin gold film. Arrays of nanogratings (1D) andnanoholes (2D) with a period of 200 nm were fabricated by electron-beam lithography andused for the detection of avian influenza DNA hybridization. Experimental results showedthat both nanoarrays provided significant sensitivity improvement and, especially, 1Dnanogratings exhibited higher SPR signal amplification compared with 2D nanohole arrays.The sensitivity enhancement is associated with changes in surface-limited reaction area andstrong interactions between bound molecules and localized plasmon fields. Our approach isexpected to improve both the sensitivity and sensing resolution and can be applicable tolabel-free detection of DNA without amplification by polymerase chain reaction.
Published Version
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