Abstract
Titanium and its alloys due to their low density, good mechanical and biological properties are of the most common orthopedic metals. One of the main challenges regarding to titanium implants is their loosening after long term implantation in patient's body. Many methods such as alteration in surface topography with focus on improving osseointegration or biocompatibility in overall are supposed to overcome this issue. In this research, titanium surface topography is altered via electrospraying a solution of titanium salt, carrier polymer (polyvinylpyrrolidone) and solvents. The dip coated samples in the same solution are prepared and investigated as control. The electrosprayed or dip coated samples were pyrolysised in furnace at 500 °C to remove polymeric components. Then the stabilized microstructures on the surfaces were evaluated via scanning electron microscopy (SEM), water contact angle (WCA) measurement, X-ray diffraction (XRD) and atomic force microscope (AFM). Also, in order to study the bioactivity of modified samples, they were immersed in simulated body fluid (SBF) and their precipitates were studied. The cellular investigations were done by studying the cell morphology, MTT and alkaline phosphatase (ALP) activity assays. The results showed improvement in bioactivity and cellular response for DP3 and SP15 more than other samples implying the promising potential of these two approaches for titanium implant surface modification.
Published Version
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