Supramolecular inclusion complexes of biodegradable cholesteryl‐(ϵ‐caprolactone)n functionalized polymer with α‐cyclodextrin

Abstract

AbstractThe biodegradable cholesteryl‐(ϵ‐caprolactone)10 (Chol‐(CL)10) functionalized polymer was synthesized and then investigated for inclusion complexation with α‐cyclodextrin (α‐CD). The supramolecular inclusion complexes (ICs) were in detail characterized by fourier transform infrared (FTIR), 1H‐nuclear magnetic resonance, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), wide angle X‐ray diffraction (WAXD), and 13C‐NMR, respectively. All analyses indicated that oligo(ϵ‐caprolactone)10 chains of the Chol‐(CL)10 were included into the hydrophobic α‐CD cavities and their original crystalline properties were completely suppressed. Moreover, the ICs of biodegradable Chol‐(CL)10 functionalized polymer with α‐CD had a channel‐type crystalline structure similar to that formed between the poly(ϵ‐caprolactone) and α‐CD. Further more, The TGA analysis revealed that the ICs had better thermal stability than their free components due to the inclusion complexation, suggesting that the complexation stabilized the polymer included in the CD chan‐nels. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007