Inclusion complexes of $$\hbox{cholesteryl-(}\varepsilon\hbox{-caprolactone})_{\overline{10}}$$ functionalized polymer with γ-cyclodextrin

Abstract

An inclusion complex (IC) of γ-cyclodextrin with biodegradable \(\hbox{cholesteryl-(}\varepsilon\hbox{-caprolactone})_{\overline{10}}\)\(\hbox{(Chol-(CL)}_{\overline{10}})\) functionalized polymer was prepared by using a general method of mixing solution. The formation of \(\gamma \hbox{-CD-Chol-(CL)}_{\overline{10}}\) IC was determined by Fourier transform infrared (FTIR),1H-NMR, differential scanning calorimetry (DSC), and wide angle X-ray diffraction (WAXD), respectively. The results indicated that the \(\hbox{oligo}(\varepsilon\hbox{-CL})_{\overline{10}}\) blocks as well as the end cholesteryl moiety of the functionalized polymer were included and covered by γ-CD in a single-stranded mode in the \(\gamma \hbox{-CD-Chol-(CL)}_{\overline{10}}\) ICs. Moreover, the \(\gamma \hbox{-CD-Chol-(CL)}_{\overline{10}}\) ICs had a channel-type crystalline structure similar to that formed between the poly(propylene glycol) (PPG) and γ-CD. Finally, TGA revealed that the ICs had better thermal stability than their free components due to the inclusion complexation.