Abstract
Suppressor of cytokine signaling (SOCS) are the negative regulators of cytokine signaling via inhibition of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. The family comprises eight structurally homologous members, including CIS (cytokine inducible SH2 containing protein) and SOCS-1 ～7. Current evidence suggests that specific members of the SOCS play a role in the development of leptin and insulin resistance owing to inhibiting leptin and insulin signaling pathways,which results in dysfunction of glucose balance and diabetes. The SOCS proteins inhibit leptin and insulin signaling by influencing multiple proteins, including insulin receptor substrate (IRS), phosphatidylinositol 3-kinase (PI3K) ,JAK leptin receptor (LR),STAT. Key words: Suppressor of cytokine signaling; Insulin resistance; Leptin resistance; Diabetes mellitus
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
