Abstract
Moderate urinary dysfunctions including frequent urination and over reactive bladder are age-related deteriorating urinary condition and saw palmetto extract and pumpkin seed oil have been used for the prevention. In the course of evaluation of activities against urinary dysfunctions in edible fruits, we found that extract of seaberry (SBE) suppressed bladder constriction. In carbacol-induced constriction in rat bladder specimen, SBE (10μg/mL) significantly suppressed the constriction. SBE also suppressed TGF-β-induced constriction of collagen gel containing bladder muscle cells. Among the constituents in SBE, ursolic acid (1–100μM) and isorhamnetin 7-O-rhamunoside (10μM) significantly suppressed carbacol-induced bladder constriction. On the other hand, 3-O-coumaroyl 2,23-dihydroxy oleanolic acid, ursolic acid, uvaol, pomolic acid, oleanolic aldehyde and isorhamnetin 7-O-rhamnoside significantly suppressed TGF-β-induced collagen gel constriction containing bladder muscle cells at 1 or 10μM. These results suggest that several triterpenoids and a flavonoid glycoside suppressed bladder constriction and SBE may contribute to suppression of urinary dysfunctions caused by overactive bladder.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.