Abstract
Publisher Summary This chapter focuses on the suppression of the in vivo humoral immune response by a species of normal human serum low-density lipoprotein. A species of normal human serum low density lipoprotein (LDL-In) has been identified with suppressive activity for in vitro human lymphocyte mitogen and allogenic cell stimulations. In a study described in the chapter, LDL-In was isolated in a partially purified form from pooled normal human serum. The effects of in vivo administration of LDL-In also were influenced by antigen dose. Additional data also was obtained on the numbers of plaque-forming cells, the mean plaque diameters and numbers of antigen-binding cells in LDL-In suppressed mice.
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