Abstract
Publisher Summary This chapter explores the role of H-2 CD antigens in secondary responses. Treatment of spleen cell suspension with UV light has been shown to selectively modify cell-surface antigens in a way that the cells are unable, after treatment, to elicit a proliferative response when used in a one-way MLC as stimulating cells. In an experiment described in the chapter, uv-treated cells syngeneic to the original stimulating cells were unable to generate any secondary cytotoxic response. However, an LD stimulus alone, presumably cross-reactive with LD antigens present on the original sensitizing cells, can restimulate a secondary cytotoxic response. When that LD stimulus is added to the CD stimulus in a three-cell experiment, a very good secondary cytotoxic response directed against that CD antigen is obtained, which is much higher than that generated by the LD stimulus alone. The potentiation seems to be specific; B10uv treated cells are unable to show the same phenomenon.
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