Abstract
The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 μM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4–Y6) receptor agonist [Leu 31,Pro 34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 μM) also attenuated the response induced by [Leu 31,Pro 34IINPY. The Y2 receptor agonist [Cys 2, Aoc 524, d-Cys 27]NPY suppressed the stimulated contractions at 1 μM only. NPY 2–36 was much less potent than NPY itself and pretreatment with BIBP3226 did not affect the inhibitory response. Human pancreatic polypeptide (Y4–Y6 receptor agonist) was inactive (≤1 μM). In conclusion, NPY is capable of suppressing sensory nerve-mediated contractions in the guinea pig bronchi mainly via Y1 receptors.
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