Abstract
Healthy male subjects were given orally a single dose of 5 mg canrenone per kg body weight. Canrenone caused a significant decrease in plasma testosterone concentration already 3 hrs after administration of the drug. Suppression of plasma testosterone concentration by 50 to 60 per cent persisted over 9 hrs. It is concluded that suppression of testosterone production is an important factor in the antiandrogenic activity of spirolactones in man.
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