Abstract
DHEA represents a promising option for the treatment of a large number of women who are really challenging for IVF specialists.
Highlights
One of the goals of Assisted Reproduction Techniques (ART) is the recruitment of multiple follicles and the recovery of good quality oocytes.Ovarian response (OR) can be defined as the reaction of the ovaries to an exogenous stimulus: it changes substantially among women and in the same woman between various cycles [1]
In literature there are several publications on poor ovarian response, but the conclusions of all these papers are the same: for the time being, there is not enough evidence to support the use of any particular regime in poor responders patients
Our still unpublished data show that Dehydroepiandrosteronesulfate (DHEA-S) administration for three months in poor responders patients can improve the peri-follicular vascularization, enhancing oxygen levels in follicular fluid, which is important in order to develop oocytes and embryo of good quality
Summary
One of the goals of Assisted Reproduction Techniques (ART) is the recruitment of multiple follicles and the recovery of good quality oocytes. The opposite of the spectrum of possible results are respectively “poor ovarian response” (POR) and “ovarian hyperstimulation syndrome” (OHSS). Incidence of poor response to ovarian stimulation during IVF treatments has been reported from 9 to 24% [2,3], but we have to consider that until ESHRE consensus in 2010 and the drafting of “Bologna criteria” on the definition of “poor response” to ovarian stimulation, the lack of a uniform definition of POR resulted in comparisons of heterogeneous groups of patients, making it very difficult to compare studies and to draw any definitive conclusions on pathogenesis, diagnosis and treatment. DHEA is abundant during female reproductive life, and progressively declines by approximately 2 percent per year [6], leading to the hypothesis that supplementation with DHEA may slow down aging process [7], considering the decrease in the ability of women to respond to ovulation-inducing medications with age. Even after 70 years of research, the physiology of DHEA is not fully understood
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