Abstract
Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL®), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy.
Highlights
According to the World Health Organization, obesity, a common denominator of Metabolic Syndrome (MetS), has in general increased three-fold worldwide since 1975
As the participation of the five different cardiovascular disease (CVD) risk factors within MetS varies among patients, we presented, as shown in Table 2, the percentage of each condition in MetS
The 22 patients with MetS showed a good tolerance to the treatment with two pills a day of the Resveratrol 50 mg + piperine 5 mg + alpha-tocopherol 25 mg (FRAMINTROL® ) formula, with no side effects
Summary
According to the World Health Organization, obesity, a common denominator of MetS, has in general increased three-fold worldwide since 1975. Lifestyle changes, such as a marked reduction in physical activity levels and an increased consumption of high-calorie foods, have been conducive to the increased prevalence of obesity. Epidemiological data from 2016 show that 39% of individuals over 18 were overweight and 13%. It has been shown that overweight and obesity are risk factors for the noncommunicable chronic diseases (NCCDs) included in MetS. MetS is a clinical disorder that is defined by the co-occurrence of other CVD risk factors, such as central obesity, abnormalities of glucose metabolism or diabetes, dyslipidemia and arterial hypertension
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