Supplementary Figure 2 from miRNA-141, Downregulated in Pancreatic Cancer, Inhibits Cell Proliferation and Invasion by Directly Targeting MAP4K4

Abstract

<p>PDF - 1052KB, Supplementary Figure S2. Inhibition of miR-141 upregulates MAP4K4 and promotes cell growth and invasion. (A) MiR-141 expression was downregulated after treated with miR-141 inhibitor. (B) Inhibition of miR-141 promoted the proliferation of PANC-1 cells by MTT assay. (C) Downregulation of miR-141 improved clonogenicity ability of PANC-1. (D) Invasion ability of PANC-1 cells was enhanced after decreasing of miR-141 expression. (E) MMP-2 and MMP-9 were upregulated after inhibition of miR-141 in PANC-1 by western blot analysis. *P<0.05, **P<0.01.</p>