Abstract
MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer.
Highlights
Snail, a family of zinc finger transcription factors, plays an important role in morphogenesis and embryogenesis
We investigated whether miR-203 was inversely correlated with Slug in gastric cancer tissues
We examined the miR-203 levels in the same six pairs of gastric cancer tissues and noncancerous tissues, and observed that miR-203 levels were decreased in gastric cancer tissues as compared to those in adjacent normal tissues (Fig. 1D)
Summary
A family of zinc finger transcription factors, plays an important role in morphogenesis and embryogenesis. The correlation between miR-203 and Slug was further examined after evaluating Slug expression in the human gastric carcinoma cell line MKN-45 after the overexpression or knockdown of miR-203. As anticipated, overexpressing miR-203 significantly increased miR203 levels and suppressed the Slug protein levels in MKN45 cells, whereas miR-203 knockdown had the opposite effect on MKN-45 expression in these cells (Fig. 2B).
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