Abstract
Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic and antipyretic effects. If it is administered in a controlled form by means of different dosing devices, it acts throughout the patient’s recovery period improving its efficacy. This study intends to support the use of supercritical solvent impregnation (SSI) as an efficient technique to develop polylactic acid (PLA) functionalized with ketoprofen, for use as controlled drug release devices. For this purpose, firstly, the influence of different SSI variables on the desirable swelling of the polymer structure, while avoiding their foaming, were evaluated. Then, the resulting ketoprofen loading was evaluated under different pressure/temperature conditions. It was generally found that as pressure and temperature are higher, the drug impregnation loads also increase. The maximum impregnation loads (at about 9% KET/PLA) were obtained at 200 bar and 75 °C. In vitro drug release tests of the impregnated compound were also carried out, and it was found that drug release profiles were also dependent on the specific pressure and temperature conditions used for the impregnation of each polymer filament.
Highlights
The use of biocompatible polymeric devices loaded with drugs or bioactive compounds is growing, and it is seen as an excellent alternative to conventional implants or to other clinical therapies
The results obtained for permanent polymer swelling, total loading and surface loading from the supercritical impregnation of ketoprofen into polylactic acid (PLA) filaments, as well as the main experimental conclusions, are presented below
The subsequent depressurization returns CO2 to a gaseous state, and it escapes from the polymeric matrix while leaving behind a series of empty cavities
Summary
The use of biocompatible polymeric devices loaded with drugs or bioactive compounds is growing, and it is seen as an excellent alternative to conventional implants or to other clinical therapies These devices allow to locally and gradually release a particular compound of interest for an improved treatment of certain disorders. The type of device and polymer to be used depends on many factors, primarily the type of drug, the dose required, and the duration of the treatment [1] Both the loading of the polymer material with the pharmacoactive substance, and the subsequent release of such substance once the device has been implanted in the patient’s body, are complex processes requiring a number of correlations between the polymer, the drug, and the medium. Important to complete a number of research studies to gain some insight into such correlations and their effects
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