Abstract
Ionizable organic compounds have been separated by supercritical and subcritical chromatography using ion-pairing modifiers. The mobile phase was carbon dioxide mixed with an acetonitrile solution containing a counter ion and a competing ion. The retention and separating efficiency are controlled by pressure and temperature as well as by the concentration and nature of the ionic mobile phase components. These highly versatile systems are applicable to polar solutes of widely different structures. The technique has been applied to the separation of enantiomeric 1,2-aminoalcohols using N-benzoxycarbonylglycyl- l-proline as a chiral counter ion. The maximum resolution and the separating efficiency at higher flow-rates are superior to that obtained in high-performance liquid chromatography.
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