Abstract
Enantiomers (optical isomers) of carboxylic and sulphonic acids have been separated in a chromatographic system having a chiral counter ion in an organic solvent as mobile phase and a surface-modified, polar silica (LiChrosorb DIOL) as adsorbing stationary phase. Separation factors of 1.3–1.5 for the enantiomers of 10-camphorsulphonic acid and moderately hydrophobic carboxylic acids have been obtained with quinine as chiral counter ion. With UV-absorbing counter ions, such as quinine and quinidine, even non-UV-absorbing acids give a response in the UV detector. The detector response and the stereoselectivity can be regulated by polar additives, e.g., 1-pentanol, and it will also depend on the anion in the mobile phase. The influence of solute and counter ion structure on the stereoselectivity is discussed. Applications of the chromatographic systems to practical problems are presented.
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