Abstract
A study of the separation of enantiomers of carboxylic and sulphonic acids as diastereomeric ion pairs with quinine as the chiral counter ion is presented. Different modified silica adsorbents have been used as stationary phases in order to regulate retention and stereoselectivity. The retention can also be controlled by the concentration of quinine and the acid in the mobile phase as well as by the relative amounts of the solvent components dichloromethane, hexane and pentanol. Stable and reproducible chromatographic systems are obtained with a low content of water (80 ppm) in the mobile phase.
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