SUN-540 No Effect Of Alcohol Use On Bone Microarchitecture Of The Distal Radius Among HIV Infected Adults

Abstract

The effect of alcohol consumption on cortical and trabecular microarchitecture is not well-understood particularly among patients living with HIV who are at higher risk for metabolic bone disease, osteopenia, and osteoporosis. The aim of this study was to assess the effect of heavy alcohol consumption on bone microarchitecture as measured by high-resolution peripheral quantitative computed tomography compared to low or no alcohol consumption among HIV-infected adults. We hypothesized that heavy alcohol consumption would have a detrimental impact on bone microarchitecture in both the cortical and trabecular compartments at the distal radius. We conducted a cross-sectional analysis among 238 participants (148 men, 42 pre-menopausal women, 48 post-menopausal women). Alcohol consumption status was based on the last 30 days (TimeLine Followback) and categorized into 4 categories based on the distribution in the study population: abstinence (0 grams(g)/day(d)) (n=82), lowest tertile (0.47 -7.0 g/d) (n=53), middle tertile (>7.0 - <35.0 g/d) (n=51), and highest tertile (35.0 - 454.1 g/d) (n=52). Bone microarchitecture measures included total volumetric bone mineral density (D100); Trabecular bone mineral density (Tb.BMD); Cortical bone mineral density (Ct.BMD); Trabecular number (Tb.N); Trabecular thickness (Tb.Th); Trabecular separation (Tb.Sp); Cortical thickness (Ct.Th); Cortical area (Ct.Ar). Associations between alcohol intake and bone microarchitecture measures were assessed using unadjusted and adjusted linear regression models. Covariates included sex, age, race, daily calcium intake, weight bearing physical activity, HIV viral load, number of years since first started taking antiretroviral therapy, intact reactive parathyroid hormone (iPTH), body mass index and number of years of heroin use. Among the density parameters, D100 was similar across all alcohol intake levels (adjusted p=0.75). The mean Tb.BMD was lowest among those who consumed low levels of alcohol (150.6 ± 41.5 mg HA/cm3) and highest among those who drank the heaviest (166.6 ± 48.6 mg HA/cm3). Mean Ct.BMD was highest with abstinence (854.8 ± 73.5 mg HA/cm3) followed by the lowest alcohol tertile (853.5 ± 60.5 mg HA/cm3) and then those reporting the heaviest drinking (829.4 ± 88.8 mg HA/cm3). However, the adjusted regression models showed no significant differences (p=0.94 and p=0.21, respectively) and remained non-significant after adjusting for 25-hydroxyvitamin D. There were no significant differences in the mean trabecular or cortical structural parameters including Tb.N (p=0.85), Tb.Th (p=0.90), Tb.Sp (p=0.73), Ct.Th (p=0.71), Ct.Ar (p=0.93) by alcohol intake after adjusting for covariates. We conclude that in this study population, bone microarchitecture measures did not differ by alcohol consumption status at the distal radius.