Abstract
Background: Delayed graft function (DGF) is a transplant complication which means a need to dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between the two oxidative stress-related factors of Superoxide dismutase (SOD) and Nitric oxide synthase (NOS) with DGF after transplantation. Materials and Methods: This case-control study was done in 2 groups of 43 kidney transplant patients with and without DGF. The control group included the patients who didn't show DGF symptoms. Then, serum levels SOD and NOS in all blood samples were measured by ELISA. Results: Serum SOD and NOS levels were significantly higher in the DGF group compared to those in the control group (p≤0.001). SOD and NOS serum levels significantly affect DGF (p<0.001) in such a way that they may be diagnostic factors of DGF. Conclusion: This study showed a significant relationship between SOD as well as NOS and DGF. Therefore, plasma levels of SOD and NOS may be used as diagnostic tools to determine the risk of DGF.
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