Abstract
The pathogenesis of IgA nephropathy (IgAN) is associated with dysregulation of immune system, however the characteristics of B cells that are responsible for production of nephritogenic IgA have been obscure. The majority of plasma cells residing in bone marrow are long-lived plasma cells, which are mainly generated via germinal center (GC) of peripheral lymphoid tissues. On the other hand, we have reported the abnormality in mucosal GC in human IgAN (JASN 28; 1227, 2017). To evaluate the abnormality in GC reaction, we used IgAN model mice.
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