Abstract
Summary of United States Human Proteome Organisation (HUPO) Symposium Entitled “Standardized Clinical Proteomics Platforms”
Highlights
Studies by the National Cancer Institute (NCI)-funded Clinical Proteomic Technologies Assessment for Cancer (CPTAC)[1] program were highlighted in a United States Human Proteome Organisation (HUPO) symposium entitled “Standardized Clinical Proteomics Platforms” on February 23, 2009
The group performed a series of studies across six participating laboratories, in which a standard operating procedure (SOP) was developed to minimize variation due to analytical methods and enable quantitative comparisons of platform performance
In proteins spiked with Sigma UPS human proteins, concordance of detection efficiency across spike concentrations against the yeast background demonstrated the feasibility of multi-laboratory comparisons of protein biomarker discovery using a standardized platform
Summary
Beginning in late 2006, the CPTAC program embarked on interlaboratory studies to evaluate proteomics platforms for unbiased discovery and targeted verification of biomarker candidates. The group performed a series of studies across six participating laboratories, in which a standard operating procedure (SOP) was developed to minimize variation due to analytical methods and enable quantitative comparisons of platform performance. This parameter facilitates comparison of the depth of proteome coverage by different analysis platforms.
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