Abstract
Sulfadiazine was quantified in two samples of pharmaceutical preparations by square-wave voltammetry. The analytical signal response was obtained by electrochemical reduction instead of oxidation of the sulfa drug at a glassy carbon electrode. The determination was carried out in 0.04 mol L-1 Britton-Robinson pH 6.8 buffer solution. Sulfadiazine reduction was observed at -1.49 V vs. Ag/AgCl in one well-resolved irreversible peak. The analytical curve was obtained in the concentration range of 62.7 to 340 µmol L-1 (r = 0.9986) with a detection limit of 10.9 µmol L-1. For one sample analyzed, recovery values were in the range of 94.9 to 101.1%, while for the other sample they were within 96.0 to 104.6%, indicating no matrix interference effects on the analytical results for both sulfadiazine samples. The accuracy of the electroanalytical method was compared to the standard amperometric titration method.
Highlights
Sulfonamides are among the most widely employed antibacterial agents in both human and veterinary medicine for prophylactic and therapeutic purposes due to their low cost and efficiency in the treatment of bacterial diseases
The aim of this paper is to describe the determination of sulfadiazine in pharmaceutical formulations using its
A simple glassy carbon electrode was used in combination with the square-wave voltammetry technique to develop a novel and alternative electroanalytical method for sulfadiazine determination through the reduction of the sulfa compound
Summary
Sulfonamides are among the most widely employed antibacterial agents in both human and veterinary medicine for prophylactic and therapeutic purposes due to their low cost and efficiency in the treatment of bacterial diseases. The widespread use of sulfonamides can lead to problems in terms of human health, taking into consideration that allergic and toxic reactions have been observed in patients treated frequently with sulfas.[1] the control of commercialized products is a permanent preoccupation for customers and manufacturers. Electroanalytical methods have been reported for the determination of sulfonamide compounds by both electrochemical oxidation[2,3,4,5,6,7,8,9] and reduction.[10,11,12,13,14,15] Electrochemical oxidation at glassy carbon and boron-doped diamond electrodes has been achieved, while the reduction reaction has been observed almost exclusively at mercury electrodes
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