Abstract
In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform—Infrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and in vitro sulfadiazine release were also investigated. The antimicrobial activity was evaluated towards three bacterial strains: Escherichia coli, Listeria monocytogenes and Salmonella thyphymurium. The developed PECs demonstrated their antimicrobial efficiency against tested bacterial strains, the PECs containing sulfadiazine-modified chitosan being more active than PECs containing unmodified chitosan.
Highlights
Dressings are applied on open wounds to protect them from injuries and bacteria invasion
polyelectrolyte complexes (PECs) are formed based on the ionic interactions established between two oppositely charged polyelectrolytes, the pH value of the solution has to be controlled in order to ensure that both molecules are on the charged form
Chitosan was functionalized with sulfadiazine without auxiliary molecules, enhancing its bacteriostatic effect and subsequently the ability to promote wound healing
Summary
Dressings are applied on open wounds to protect them from injuries and bacteria invasion. An ideal dressing should maintain a moist environment at the wound interface, allow gaseous exchange, act as a barrier to microorganisms, and remove excess exudates. It should be non-toxic, non-allergenic, non-adherent and be removed without trauma; it should be made from a readily available biomaterial that requires minimal processing, possesses antimicrobial properties and promotes wound healing. Dressings made from natural or semisynthetic polymers are increasingly used to deliver drugs to acute, chronic and other types of wounds Chitin, chitosan, and their derivatives, prepared in various forms as hydrogels, nanofibers, membranes, micro/nanoparticles and sponges are promising biomaterials for wound dressing and other biomedical applications, such as drug and gene delivery, tissue engineering, etc. These have excellent properties being adhesive, biocompatible, biodegradable, nontoxic, hydrophilic, having antimicrobial effect and oxygen permeability [6,7]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call