SU-E-T-264: Development of Dose Response Analysis Program for Basic Radiobiological Modeling

Abstract

Purpose: To verify and quantify various dose responses including estimated survival fraction(SF) through clonogenic assay, estimated model parameters and its uncertainty, and relative biological effectiveness(RBE) and its uncertainty for each model. Methods: An user-friendly program, dose response analysis program(DREAP, ver.2.0) was developed by using Matlab. The program can provide two types of calculation modes at present. First, the “calculation of SF” mode is designed for giving estimated SF curves, model parameters, and its uncertainty at specific confidence level. it provides five types of established SF models such as linear quadratic(LQ), universal survival curve(USC), multi-target single-hit(MTSH) model, and repair kinetics models including repair mis-repair(RMR) and lethal potentially-lethal(LPL) model. Second, the “calculation of RBE” mode is made for giving estimated RBEs at a broad range of survival levels and its uncertainty at 95 percent confidence level. This mode gives three established SF models except for repair kinetics models. All the modes include basic analysis and comparison tools for each mode. And, all relevant and quantitative results can be easily exported to excel format by one mouse-click. Results: The “calculation of SF” mode can give SF curve through clonogenic assay data, and its uncertainty for each five SF models. Also, the “calculation of RBE” mode can provide RBE and its uncertainty for each three SF models. Since these modes have a feature of interactive and user-friendly structure, the user can easily quantify and access to a variety of dose responses results. Conclusion: The program can provide an easy way to access dose response results with interactive graphical user interfaces(GUIs). The features stated above will make the program practical to use for particle therapy center which needs to collect expected model parameters and its uncertainty, and manage meaningful RBE database.