Abstract
Sugars are known to strongly affect lipid-water phase behavior and often serve as protectants against cold, heat, and dehydration. However, a detailed picture of how sugars interact with lipids remains an active question. We have determined the phase diagram of the lipid SOPE (1-stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine) as a function of sucrose concentration by means of DSC and laser-light scattering. Using thermodynamic arguments, our data can be used to determine the interfacial concentration of sucrose in lipid-water-sucrose mixtures. Our preliminary results are consistent with a model of sucrose being excluded in a thin layer of water immediately in front of the lipid head groups, but partially included in the gaps between lipid head groups in the fluid lamellar phase and in the core of the inverted hexagonal phase.
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