Successful treatment of sino-pulmonary infection & skull base osteomyelitis caused by New Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa in a renal transplant recipient by using an investigational antibiotic cefepime/zidebactam (WCK 5222).

Rajeev Soman,Camilla Rodrigues,Balaji Veeraraghavan,Ayesha Sunavala,Rasika Sirsat,Jugal Mehta,Neha Punatar

doi:10.1007/s10096-024-04791-1

Successful treatment of sino-pulmonary infection & skull base osteomyelitis caused by New Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa in a renal transplant recipient by using an investigational antibiotic cefepime/zidebactam (WCK 5222).

Rajeev Soman, Camilla Rodrigues + Show 5 more

https://doi.org/10.1007/s10096-024-04791-1

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Journal: European Journal of Clinical Microbiology & Infectious Diseases	Publication Date: Feb 28, 2024
Citations: 3

#Individualized Dose Adjustments #Antibiotic Options #Renal Transplant Recipient #Source Control #Case Of Infection #Skull Base Osteomyelitis #Sino-pulmonary Infection #Skull Base #Dose Adjustments #Renal Transplant

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A case of sino-pulmonary infection with skull base osteomyelitis due to XDR-Pseudomonas aeruginosa in renal transplant recipient was successfully treated with investigational antibiotic, cefepime/zidebactam (WCK 5222). This case highlights challenges in managing XDR-pseudomonal infection where source control was infeasible, antibiotic options were extremely limited and individualized dose adjustments were needed.

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Successful treatment of sino-pulmonary infection & skull base osteomyelitis caused by New Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa in a renal transplant recipient by using an investigational antibiotic cefepime/zidebactam (WCK 5222).