Successful treatment of recurrent uric acid renal calcui with probenecid (benemid).

Abstract

Case Reports1 July 1958SUCCESSFUL TREATMENT OF RECURRENT URIC ACID RENAL CALCULI WITH PROBENECID (BENEMID)ARTHUR BERNSTEIN, M.D., F.A.C.P., DAVID BRONSKY, M.D., ALVIN DUBIN, M.S.ARTHUR BERNSTEIN, M.D., F.A.C.P.Search for more papers by this author, DAVID BRONSKY, M.D.Search for more papers by this author, ALVIN DUBIN, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-1-203 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUric acid stones comprise 4 to 6%1, 2 of all renal calculus disease. Treatment by surgical and dietary measures, by alkalinization of the urine and with salicylates has not been satisfactory. Such stones occur frequently in patients with gout. Probenecid (Benemid), a potent uricosuric agent, may effect a reversal of the clinical course of gout.3, 4 That it may also be highly effective in the treatment of recurrent uric acid stones in patients without symptomatic gout can be inferred by a consideration of the following case history.CASE REPORTA 64 year old white man was observed on January 2,...Bibliography1. BurklandRosenberg CEM: Survey of urolithiasis in United States, J. Urol. 73: 198-207, 1955. CrossrefMedlineGoogle Scholar2. Prien EL: Studies in urolithiasis, J. Urol. 61: 821-836, 1949. CrossrefMedlineGoogle Scholar3. Bartels EC: Gout—now amenable to control, Ann. Int. Med. 42: 1-10, 1955. LinkGoogle Scholar4. GutmanYü ABTF: Prevention and treatment of chronic gouty arthritis, J. A. M. A. 157: 1096-1102, 1955. CrossrefMedlineGoogle Scholar5. LearOppenheimer HGD: Anuria following radiation therapy in leukemia, J. A. M. A. 143: 806-807, 1950. CrossrefMedlineGoogle Scholar6. McCrea LE: Formation of uric acid calculi during chemotherapy for leukemia, J. Urol. 73: 29-34, 1955. CrossrefMedlineGoogle Scholar7. KuzellSchaffarzickNauglerKoetsMankleBrownChamplin WCRWWEPEABB: Some observations on 520 gouty patients, J. Chron. Dis. 2: 645-669, 1955. CrossrefMedlineGoogle Scholar8. KittredgeDowns WER: The role of gout in the formation of urinary calculi, J. Urol. 67: 841-847, 1952. CrossrefMedlineGoogle Scholar9. BenedictYüBienGutmanStetten JDTFEJABD: A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout, J. Clin. Investigation 32: 775-777, 1953. CrossrefMedlineGoogle Scholar10. Hench PS, in Cecil and Loeb, Textbook of medicine, 9th Ed., 1955, W. B. Saunders Co., Philadelphia, pp. 651-652. Google Scholar11. Talbott JH: The diversity of gouty arthritis and its complications, Ann. Int. Med. 31: 555-569, 1949. LinkGoogle Scholar12. PascalDubinHoffman LRAWS: Therapeutic value of probenecid (Benemid) in gout, J. A. M. A. 149: 1188-1194, 1952. CrossrefMedlineGoogle Scholar13. Talbott JH: Gout and gouty arthritis, 1953, Grune & Stratton, New York, p. 74. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication January 7, 1957.From the Hektoen Institute for Medical Research of the Cook County Hospital and the Department of Medicine, University of Illinois.Requests for reprints should be addressed to Arthur Bernstein, M.D., 25 East Washington Street, Chicago 2, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal calculi preceding gouty arthritis in a childRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (THIRTEENTH RHEUMATISM REVIEW)*CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P.(C), MAX M. MONTGOMERY, M.D., F.A.C.P., HOWARD F. POLLEY, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CARLOS F. SACASA, M.D., F.A.C.P., OTTO STEINBROCKER, M.D., HANS WAINE, M.D., GEORGE M. WILSON JR., M.D.HYPERURICÆMIC KIDNEY DISEASE 1 July 1958Volume 49, Issue 1Page: 203-207KeywordsExcretionGoutHospital medicineHypertensionIngestionKidney stonesRenal diseasesSalicylatesUric acidUrine Issue Published: 1 July 1958 PDF downloadLoading ...