Abstract
Bleeding and transfusions following cardiac surgery significantly increase the rate of complications. Early diagnosis of "surgical" and "coagulopathic" bleeding is a prerequisite for effective treatment. Thromboelastometry with targeted hemostasis therapy can help in setting up the indication for reoperation and reduction of blood loss, transfusions and costs. We aimed to develop a local "reoperation for bleeding" protocol derived from the data of our former patients. Based on data from 1011 cardiac surgical patients (control group), we developed a statistical algorithm to distinguish between "coagulopathic" and "surgical" bleeding. We used viscoelastic coagulation test and risk stratification. In 112 consecutive patients (study group), we examined the reoperations, and the impact of the protocol on the rates of transfusions and treatment costs. There was no difference in the rate of reoperations between the two groups (6.2% vs. 5.4%; p = 0.584). No coagulopathic bleeding occurred in the study group, compared to 12.7% in the control group. In the study group, we experienced reduction in bleeding (p = 0.026), an increased application of fibrinogen (p<0.001), prothrombin complex concentrate (p<0.001), and tranexamic acid (p<0.001). Red blood cell transfusions decreased by 30% (1.7±2.6 E vs. 2.3 ± 3.3 E; p = 0.012). No difference was found in the amounts of fresh frozen plasma or platelet transfusions used. Calculated cost savings were HUF -20,333 per patient. Using this algorithm, reoperations were performed only in cases of surgical bleeding. The amount of bleeding, requirement for transfusions and treatment costs were reduced. Orv Hetil. 2020; 161(34): 1414-1422.
Highlights
Bleeding and transfusions following cardiac surgery significantly increase the rate of complications
Thromboelastometry with targeted hemostasis therapy can help in setting up the indication for reoperation and reduction of blood loss, transfusions and costs
Aim: We aimed to develop a local “reoperation for bleeding” protocol derived from the data of our former patients
Summary
Reoperációs algoritmus és célvezérelt haemostasisterápia együttes, sikeres alkalmazása súlyos szívsebészeti vérzés kezelésében. Módszer: Az osztályunkon korábban operált 1011 beteg (kontrollcsoport) adataiból a coagulopathiás és a ’sebészi’ vérzés megkülönböztetésére statisztikai algoritmust hoztunk létre. Eredmények: A vérzés miatt végzett reoperáció gyakorisága nem különbözött a vizsgált és a kontrollcsoport között (6,2% vs 5,4%; p = 0,584). A vérzéses-reoperációs protokoll alkalmazása mellett csökkent a vérzés (p = 0,026), több betegnél alkalmaztunk fibrinogént (p
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