Success and use of Stem Cells in Bone Regeneration of the Oral Cavity Systematic Review

Abstract

Tissue engineering using mesenchymal stem cells (MSCs) is a recent therapy modality that has multiple advantages. One of them is the ability to accelerate hard and soft tissue repair processes thanks to, in part, its proliferative and regenerative capacities, improving morbidity postoperative of the patients. Therefore, the main objective of this review system is to be able to identify the current uses of MSCs in regenerative therapies bones of the oral cavity. In recent years, various articles have been published in where we talk about the advances that have been made in regenerative treatments. The regeneration of lost oral tissues is the objective of research in MSCs. For this reason, it is important that the main characteristics of therapies with MSCs are understood by clinicians so that they can be used in the future. Objective: To describe the success and use of MSCs for bone regeneration of the oral cavity. Material and method: A search in the PUBMED, STEM CELLS databases JOURNAL and MICROSOFT ACADEMIC was made to include clinical studies (randomized and controlled), case controls or series of cases that describe the use of human mesenchymal cells (MSC’s) for bone regeneration surgeries in the oral cavity, specifically. Results: 147 articles were found, after reading the title and abstracts 107 articles were selected, 99 were eliminated after evaluating inclusion criteria and exclusion, 8 articles were selected to carry out a complete reading of the text. The selected articles are: 2 randomized clinical cases, 3 cases nonrandomized controlled trials and 3 case series reports. the site for obtaining MSCs that used the most corresponds to the bone marrow. with the results of the articles included in this study, it is observed that the mesenchymal cells intraoral would have the capacity to carry out new formation of bone tissue. Conclusion: It is necessary to specify a storage and transport protocol for the MSCs. Studies using MSCs extracted from other donor sites are lacking. intraoral. Good results were found in tissue regenerative treatments bone tissue incorporating cellular technology into its procedures.