Subtle Brain Lesions and Mental Impairment in Sickle Cell Disease

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Neurology| May 01 1999 Subtle Brain Lesions and Mental Impairment in Sickle Cell Disease AAP Grand Rounds (1999) 1 (5): 37–38. https://doi.org/10.1542/gr.1-5-37 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Subtle Brain Lesions and Mental Impairment in Sickle Cell Disease. AAP Grand Rounds May 1999; 1 (5): 37–38. https://doi.org/10.1542/gr.1-5-37 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: brain lesions, mental state abnormal, sickle cell anemia Source: Steen RG, Xiong X, Mulhern RK, Langston JW, Wang WC. Subtle brain abnormalities in children with sickle cell disease: relationship to blood hematocrit. Ann Neurol. 1999;45:279–286. The risk of subtle brain abnormalities in children with sickle cell disease (SCD) and their relationship to hematocrit was determined by prospective comparison of 50 patients (average age 10.6 years with range of 4.3 to 17.9 years) and 52 controls studied at St. Jude Children’s Research Hospital, Memphis, Tennessee. Using quantitative magnetic resonance imaging to measure T1 (spin-lattice relaxation time) in basal ganglia (50 patients and 52 controls) and the Wechsler test of intelligence (27 patients), patients by age 4 years showed a significantly lower T1 (evidence of structural changes at the cellular level) in basal ganglia and cortex, but not in white matter. These patients also demonstrated mild mental deficiency (IQ 50–70) in 33%, compared to a... You do not currently have access to this content.