Abstract
Inspired by the modest success of a phenoxyphenylacetic acid ( I) biphenyl tetrazole replacement, 1,3-benzodioxole-2-carboxylates and 1,3-benzodithiole-2-carboxylates ( II) and their respective tetrazole analogs ( III) were investigated as AII antagonists. These compounds, essentially conformationally restricted analogs of the phenoxyphenylacetic acid series, proved to be quite potent in vitro.
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