Abstract
This study aimed at evaluating results of mitral valve replacement using a new technique of complete chordae tendineae adjustment for left ventricular remodeling. Twenty end-stage idiopathic dilated cardiomyopathy patients with severe functional mitral valve regurgitation underwent mitral valve replacement. Seventeen (85%) were in functional class IV. Both anterior and posterior leaflets of the mitral valve were divided to obtain 4 pillars of chordae tendineae. These were displaced with traction toward the left atrium and anchored between the mitral annulus and a valvular prosthesis. To evaluate the left ventricular remodeling, Doppler echocardiography was performed. For statistical analysis, variance analysis and the Friedman's test were employed. Two (10%) early deaths occurred. Kaplan-Meyer showed survival at one year post-operative was 85%, 2 years it was 44%, at 3 years 44%, at 4 years 44% and at 5 years it was 44%. In the 48- and 54-month follow-ups, the McNemar test showed improvement in the functional class (p<0.001). In the third month of follow-up, variance analysis showed improvement in the ejection fraction (p=0.008) and reductions of the end diastolic diameter (p=0.038), end systolic diameter (p=0.008), end systolic volume (p=0.029) and end diastolic volume (p=0.009). No statistical differences were noted in the systolic volume. Comparing pre-operative and third- and six-month follow-ups, the Friedman test showed no statistical differences for all studied variables. Variance analyses between pre, three-month and final evaluations showed no significant differences. This technique of mitral valve replacement improved the left ventricle ejection fraction and decreased the end diastolic and systolic diameters and the end systolic diastolic volumes up to the third month of follow-up. From then on the variables stabilized.
Highlights
Secondary mitral valve insufficiency is commonly present in advanced stage dilated myocardiopathy
Article received in April 26th, 2006 Article accepted in December 26th, 2006
GAIOTTO, FA ET AL - Mitral valve replacement with chordae tendineae preservation, traction and fixation in end-stage dilated cardiomyopathy of the end diastolic diameter (p=0.038), end systolic diameter (p=0.008), end systolic volume (p=0.029) and end diastolic volume (p=0.009)
Summary
Secondary mitral valve insufficiency is commonly present in advanced stage dilated myocardiopathy. There are mitral ring dilatation and transvalvar pressure alterations that, together with the subvalvar alterations cause secondary mitral valve insufficiency. The association of dilated myocardiopathy with secondary mitral valve insufficiency causes refractivity to clinical treatment and high mortality, mainly in Functional Class III and IV patients (NYHA). Heart transplantation is the best treatment method for advanced heart failure, with good survival rates over the first 5 years, but, there are insufficient donors thereby limiting its use. In the United States between 6000 and 8000 patients per year join the waiting list for transplants. Mortality on the waiting list is high (40% to 50%). Many patients leave the waiting list or do not enter it due to contraindications for heart transplantation
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