Substance P Accelerates Secretory Component-Mediated Transcytosis of IgA in the Rat Intestine

Dennis Mcgee,Serem Freier,Maya Eran,Jerry R Mcghee

doi:10.1007/978-1-4615-1941-6_135

Substance P Accelerates Secretory Component-Mediated Transcytosis of IgA in the Rat Intestine

Dennis Mcgee, Serem Freier + Show 2 more

https://doi.org/10.1007/978-1-4615-1941-6_135

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Publication Date: Jan 1, 1995

Citations: 4

Affiliation: University of Alabama at Birmingham, Shaare Zedek Medical Center

#Secretion Of Specific Antibodies #Substance P + Show 8 more

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Abstract

We have previously shown that cholecystokinin (CCK) causes secretion of specific IgA antibodies in the rat intestine.1 The objective of the experiments described below was to establish if another gut-brain peptide, substance P (SP), also accelerates secretion of IgA. The reason for choosing this peptide was that SP is functionally similar to CCK, though chemically quite unrelated. Once having established that SP, indeed, causes secretion of IgA specific antibodies, we proceeded to obtain data on the molecular size of the IgA, on its probable mode of transport and on the absolute amounts secreted.

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