The Immunoglobulin a System

Abstract

Session A Developmental and Cellular Aspects Chairman: Lars A. Hanson.- The IgA System in Connection with Local and Systemic Immunity.- Origin, Distribution, and Differentiation of IgA-Producing Cells.- Cell Types Contributing to the Biosynthesis of sIgA.- DISCUSSION I.- Gut-Associated Lymphoblasts and Intestinal IgA Plasma Cells.- Bronchial Lymphoid Tissue.- The Origin of Monomeric and Polymeric Forms of IgA in Man.- Cytophilic Properties of IgA to Human Neutrophils.- DISCUSSION II.- Session B Structure, Biosynthesis, and Genetics Chairman: J. Claude Bennett.- Characteristics of SC-Ig Complexes Formed in vitro.- Association of S-IgA Subunits.- Modulation of the Assembly of Immunoglobulin Subunits.- DISCUSSION I - E. C. Franklin, Initial Discussant.- Mechanism of Immunoglobulin Polymer Assembly.- Assembly and Secretion of Immunoglobulin A.- Special Characteristics of the IgA2 Subclass.- Genetics and Evolution of Human Immunoglobulin A.- Physical-Chemical Characteristics of J Chains Obtained from IgM.- DISCUSSION II.- Session C Structure Chairman: Jiri Mestecky.- Isolation, Properties, and Structure of Human IgA Myeloma Globulins.- Amino Acid Sequence Studies of Human IgA Myeloma Proteins.- Structural Studies on a Human IgA1 Myeloma Protein with a Carboxy Terminal Deletion.- The Hinge Peptide of an IgA2m(2) Myeloma Protein.- The Carbohydrate Composition of Glycopeptides Isolated from IgA2 Immunoglobulin.- Mouse IgA Myeloma Proteins with Alpha Chain Deletions: A Comparison with Human Alpha Chains with Deletions.- DISCUSSION I.- Evidence for a Common Synthetic Origin for Secretory and Serum IgA.- Studies on the Primary Structure of Human Secretory Component.- Production of an Fc Fragment from Human Immunoglobulin A by an IgA-Specific Bacterial Protease.- Precipitin Cross-Reactions between Human and Animal J-Chains.- Disulfide Bridges of Human Immunoglobulins A1 and A2.- DISCUSSION II.- Session D Function Chairman: Frederick W. Kraus.- Implications of Secretory Immune System in Viral Infections.- The Role of the Secretory Immune System in Protection Against Agents Which Infect the Respiratory Tract.- The Role of Immunization in Controlling Antigen Uptake from the Small Intestine.- Lack of C3 Activation through Classical or Alternate Pathways by Human Secretory IgA Anti-Blood Group A Antibody.- DISCUSSION I.- Bacterial Adherence to Mucosal Surfaces and Its Inhibition by Secretory Antibodies.- Specificity of Antibodies to Streptococcus Mutans Significance in Inhibition of Adherence.- Secretory Antibodies in Milk of Swine Against Transmissible Gastroenteritis Virus.- Secretory IgA and Direct Killing of Shigella by Serum Components.- DISCUSSION II.- Session E Clinical Considerations Chairman: Max D. Cooper.- Current Knowledge on Alpha Chain Disease.- The Cellular Basis of IgA Deficiency in Humans.- Alpha Chain Determinants on the Membrane of Immunoglobulin Synthesizing Cells.- Secretory and Serum IgA in Children with Protein-Calorie Malnutrition.- Studies of Secretory Antibodies to E. Coli in Human Urine Compared to the Serum Antibody Content.- Secretory IgA: An Adolescent Coming of Age.- DISCUSSION I.- Types of Size Heterogeneity of IgA Molecules Isolated from Myeloma and Normal Human Serum.- Distribution of IgA Subclasses in Sera and Bone Marrow Plasma Cells of 21 Normal Individuals.- Selective IgA Deficiency and Chronic Obstructive Pulmonary Disease - A Family Study.- DISCUSSION II.- Session F The IgA Antibody Response Implications for Oral Health Chairman: Alexander R. Lawton.- The Induction and Characterization of Secretory IgA Antibodies.- Human Nasal Exocrine IgA Antibody: Formation and Some Activities.- The IgA Antibody-Forming Cell Response in the Rabbit Submandibular Gland Following Several Different Methods of Immunization.- The Establishment of Systemic Immunity Following Antigenic Stimulation of the Lymphoid Tissue of the Gastrointestinal Mucosa.- DISCUSSION I.- The Relationship between Serum and Salivary Antibodies and Cell Mediated Immunity in Oral Disease in Man.- Oral Manifestations of IgA Deficiency.- DISCUSSION II.- Conclusion.- Impressions, Summary, and Questions Raised by the IgA Symposium.- Program Participants.