Abstract
Large-cell lymphoma can be difficult to diagnose because vitreous biopsies may fail to disclose neoplastic cells. We report one such case in which diagnosis was confirmed by subretinal aspiration of yellow-white infiltrates using a pars plana approach. A 67-year-old woman with recurrent bilateral uveitis was diagnosed with large-cell lymphoma by subretinal aspiration of yellow-white infiltrates after two vitreous biopsies and a concurrent retinal biopsy failed to confirm the diagnosis. When the suspicion of intraocular lymphoma remains high despite previous negative vitreous biopsies, retinal biopsy and aspiration biopsy of subretinal lesions may enhance the diagnostic yield.
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