Subregional parcellation and segmentation of the prefrontal cortex in children – Protocol calibration

Abstract

Event Abstract Back to Event Subregional parcellation and segmentation of the prefrontal cortex in children – Protocol calibration M. A. Garcia-Barrera1*, J. Hatter1, N. Trujillo-Orrego2, K. Gicas1, J. Wilson1 and G. W. Hynd3 1 CORTEX, University of Victoria, Department of Psychology, Canada 2 University of Antioquia, Neuroscience Group, Colombia 3 College of Charleston, United States Due to its functional association to executive functioning, the study of the morphological configuration of prefrontal cortex (PFC) in neurodevelopmental disorders is of great relevance in neuropsychology. One robust example comes from the neuroimaging literature in Attention Deficit/Hyperactivity Disorder (ADHD). Our study aimed to examine the sensitivity of a PFC parcellation protocol to detect cortical differences, after a refined calibration and when applied to a preliminary pediatric sample of children with ADHD (n=5) and matched controls. Our protocol included parcellation and manual tracing following a semi-automated extraction of each Region of Interest (namely ventromedial, orbitolateral, dorsomedial and dorsolateral) and subsequent gray/white matter segmentation using Analyze 9.0 (Mayo Clinic, 2009) on a series of structural MRIs. Results demonstrated the sensitivity of our protocol to detect small scale differences in gray and white matter thickness, characterized by a significant (p< 0.05) smaller bilateral dorsomedial gray cortical PFC volume in the ADHD group while a trend towards a thicker white matter volume in left dorsolateral areas was also found in ADHD and after controlling for total brain volumes. These differences were not captured by a total PFC volume analysis. Intra and inter-rater tracing reliabilities were above criterion (> .90) for all areas. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Frontal Lobe Development Citation: Garcia-Barrera MA, Hatter J, Trujillo-Orrego N, Gicas K, Wilson J and Hynd GW (2010). Subregional parcellation and segmentation of the prefrontal cortex in children – Protocol calibration. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00061 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Jun 2010; Published Online: 28 Jun 2010. * Correspondence: M. A Garcia-Barrera, CORTEX, University of Victoria, Department of Psychology, Victoria, Canada, mgarcia@uvic.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers M. A Garcia-Barrera J. Hatter N. Trujillo-Orrego K. Gicas J. Wilson G. W Hynd Google M. A Garcia-Barrera J. Hatter N. Trujillo-Orrego K. Gicas J. Wilson G. W Hynd Google Scholar M. A Garcia-Barrera J. Hatter N. Trujillo-Orrego K. Gicas J. Wilson G. W Hynd PubMed M. A Garcia-Barrera J. Hatter N. Trujillo-Orrego K. Gicas J. Wilson G. W Hynd Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.