Abstract
Oral squamous cell carcinoma (OSCC) is a differential diagnosis of subgemmal neurogenous plaque (SNP), however cases of both adjacent lesions is extremely rare. Usually, SNP is associated with severe and persistent pain, a symptom rarely seen in early-stage OSCC. Here, we present a 47-year-old female patient complaining of severe pain upon touch, eating, or drinking in the posterior third of the lateral border of the tongue for one year, which was diagnosed as SNP. However, the symptoms did not decrease, and changed location to the middle third of the lateral border of the tongue, together with the appearance of a new lesion, which was diagnosed as OSCC. While the simultaneous occurrence of OSCC and SNP in the oral cavity is uncommon, pain has been reported as the initial symptom of malignancy in such cases.
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