Abstract
The prevalence of Metabolic syndrome (MetS) in Sichuan of China has not yet been estimated. Meanwhile the association among anxiety, subclinical hypothyroidism (SCH) and MetS was less well-studied. The data was retrieved retrospectively from Health Promotion Center of West China Hospital database between 2014 and 2017. Internal validation by randomizing into training and testing panel by 9:1 and external validation with National Health and Nutrition Examination Survey (NHNES) were conducted. 19006 subjects were included into analysis, and 3530 (18.6%) of them were diagnosed with MetS. In training panel, age, sex (male), SCH (presence), SAS score, alcohol (Sometimes & Usual) and smoking (Active) were identified as independent risk factors for MetS, which was confirmed in testing panel internally. NHNES data validated externally the association between free thyroxine (fT4) and MetS components. The C-indices of predicting MetS nomogram were 0.705 (95% CI: 0.696–0.714) and 0.728 (95% CI: 0.701–0.754) in training and testing panel respectively. In conclusion, MetS prevalence was 18.6% in Sichuan. SCH and anxiety may be associated with MetS independently. A risk scale-based nomogram with accurate and objective prediction ability was provided for check-up practice, but more cohort validation was needed.
Highlights
Metabolic syndrome (MetS) is characterized by a cluster of type 2 diabetes, cardiovascular disease risk factors, including hyperglycemia, central obesity, dyslipidemia and hypertension
MetS-related risk factors vary in previous different researches, yet consensus was reached that variables-age, body mass index, socioeconomic and lifestyle characteristics were defined as risk factors[4]
21477 subjects underwent complete physical examination in Health Promotion Center of West China Hospital from 2014 to 2017. 1295 of them were diagnosed with overt hypo/hyperthyroidism and were removed from final analysis. 487 and 689 were excluded because of no provided written informed consent and incomplete information, respectively
Summary
Metabolic syndrome (MetS) is characterized by a cluster of type 2 diabetes, cardiovascular disease risk factors, including hyperglycemia, central obesity, dyslipidemia and hypertension. Yoshifumi Koshino et al found the association between clinical features of anxiety and thyroid hormone level[7]. It may be explained by the physiological interaction function between nervous and endocrine system partly[8,9]. Subclinical hypothyroidism affects up to 10% of the population, with the highest prevalence among women and elderly individuals[10,11]. It gradually www.nature.com/scientificreports becomes a public concern in population. We orchestrated to explore the MetS prevalence in SC province in the hospital-based population study, and investigated the relationship among anxiety, SCH and MetS
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