Abstract
SALATRIM 23CA lot A014, SALATRIM 32CA lot A015, and SALATRIM 23SO lot A026 are members of a family of structured triacylglycerols having caloric densities of 4.5-6.0 kcal/g. Rats received 0%, 2%, 5% and 10% of the first two SALATRIM fats or 10% corn oil in the diet for 13 weeks. Body weight and feed consumption were unaffected. Minimally increased urinary phosphorus clearance occurred in 10% SALATRIM groups. Bone mineral variations and an increased incidence of renal mineralization occurred in 10% SALATRIM and corn oil fed rats. These changes appeared to be directly related to the quantity of unsaturated fatty acids in the high-fat diets. Measurements of serum and liver fat-soluble vitamin concentrations, necropsy, clinical pathology, organ weights, and histopathology revealed no SALATRIM-related effects. Corn oil produced hepatocellular vacuolation. In a supplementary short-term study, 10% dietary SALATRIM 23SO lot A026 produced no effect on selected serum transaminases. Overall, the SALATRIM fats produced no toxicologically significant effects.
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