Abstract
AbstractMale Sprague-Dawley rats were exposed 6 hr/day, 5 days/week for up to 13 weeks to aged and diluted sidestream smoke (ADSS), used as a surrogate for environmental tobacco smoke (ETS), at concentrations of 0.1 (“typical”), 1 (“extreme”), or 10 (“exaggerated”) mg of particulates/m3. Subgroups of animals were killed after 1 and 4 weeks of exposure. Animals were exposed nose-only, inside whole-body chambers, to ADSS from the 1R4F reference cigarette. End points included histopathology, CO oximetry, plasma nicotine and cotinine, clinical pathology, and organ and body weights. The target particulate concentrations were achieved; at the exaggerated exposure they resulted in CO concentrations in excess of 50 ppm. Particle size distributions showed that the aerosols were completely respirable: the mass median diameter values were less than 1 μm. The only pathological response observed was slight to mild epithelial hyperplasia in the rostral nasal cavity, in the exaggerated exposure group only. No effects we...
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