Abstract
AbstractResin‐based materials (RBMs) are widely applied in dentistry because they withstand the recurrent multi‐dimensional force striking and the hydrolysis of teeth. Sub‐nanoscale materials can enhance the mechanical strength and bioactivity of RBMs, but the effects are still limited and the mechanisms to enhance bioactivity remain unclear. Here, a TiO2‐based sub‐nanocomposite modified with caffeic acid (CA) to enhance mechanical robustness, structural stability, and bioactivity of RBMs is reported. This sub‐nanocomposite can promote the proliferation, adhesion, and odontogenic differentiation of human dental pulp stem cells (hDPSCs) through specifically up‐regulating the expression of genes related to cell‐matrix adhesion, integrin‐mediated signaling pathways, and collagen fibril organization. These effects lead to a better capacity for up‐regulating odontogenic differentiation of RBMs.
Published Version
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