Abstract
In this study, the effects of crocin and safranal were studied against sub-acute toxicity of diazinon (DZN) on specific biomarkers, biochemical indices and enzymes levels in rats. Vitamin E (200IU/kg), safranal at doses 0.025, 0.05 and 0.1ml/kg and crocin at doses 50, 100 and 200mg/kg were injected intraperitoneally three times per week alone or with DZN (20mg/kg/day, orally) for 4weeks. The parameters were evaluated at the end of 4weeks. Diazinon did not change serum urea, creatinine, cholesterol, triglyceride, total and direct bilirubin levels. Total protein and albumin concentrations were decreased by diazinon. Crocin, safranal and vitamin E prevented the effect of diazinon on some biochemical indices and enzymes levels. The levels of serum TNF-α, direct 8-iso-prostaglandin F2α and soluble protein-100 β (S100β) were increased significantly by diazinon. The augmentation of direct 8-iso-prostaglandin F2α and S100β levels by diazinon was significantly decreased by crocin, safranal and vitamin E. TNF-α level was significantly decreased in diazinon plus crocin 50 and 100mg/kg treated groups compared to the diazinon group. This study showed that vitamin E, safranal and crocin could prevent diazinon induced enzymes elevation and augmentation of some specific biomarkers.
Published Version
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