SU65 - ASSOCIATION OF POLYMORPHISM RS934945 GENE PER2 WITH SLEEP DISODERS IN THE MALE POPULATION 25–44 YEARS IN NOVOSIBIRSK

Abstract

Background To study the prevalence and associations of gene PER2 with sleep disorders. Methods A random representative sample of the male population aged 25–44 years who were residents of one of Novosibirsk district was examined in 2014–2016. Results The most common genotype of rs934945 PER2 gene was genotype G / G - 65,36%. A/G was in 30.17% and genotype A/A was in 4,47% of men. Those carriers with the A/A genotype has an increasing tendency of anxious dreams during sleep compared to carriers of other genotypes. Carriers of genotype A / A often wake up during the night. Sleep was the strongest in men with A / G and G / G genotype. Lack of sleep (5 hours or less) is also more common in persons who had genotype with homozygous allele A was presented in. Discussion The gene PER2 (rs934945) in our population has a relationship with various chronotype that plays an important role in understanding the basics of sleep disorders.