Abstract
Alcohol withdrawal is the most threatening condition encountered in patients with alcohol use disorder. Our study aimed to investigate the association of alcohol withdrawal severity with polymorphic variants in melatonin receptor genes. Methods. The clinical study was carried out on the basis of the Republican Narcological Dispensary №1 in Ufa and the Republican Narcological Dispensary №2 in Sterlitamak. Genetic analysis was performed at the Department of Personalised Psychiatry and Neurology at the V.M. Bekhterev Research Centre, Saint Petersburg. The final sample consisted of 307 subjects. Results. Carriers of the TT genotype of the MTNR1A gene (rs34532313) were found to have less hypertension during alcohol withdrawal than carriers of the other genotypes. In comparison, carriers of the GG genotype of the MTNR1B gene (rs10830963) experienced more symptoms than other genotypes: paroxysmal sweating, visual hallucinations, anxiety, and overall CIWA-Ar score. Conclusions. Thus, it can be concluded that the TT genotype of MTNR1A gene (rs34532313) is associated with a lower risk of hypertension during alcohol withdrawal compared to carriers of other gene genotypes. The GG genotype of MTNR1B gene (rs10830963) is associated with severe withdrawal. In general, it can be concluded that melatonin receptors are involved in the pathogenesis of alcohol withdrawal and the severe of some of its symptoms.
Highlights
Alcohol use problems remain a matter of concern to modern public health
Our study aimed to investigate the association of alcohol withdrawal severity with polymorphic variants in melatonin receptor genes
It can be concluded that melatonin receptors are involved in the pathogenesis of alcohol withdrawal and the severe of some of its symptoms
Summary
Alcohol use problems remain a matter of concern to modern public health. At the end of 2018, according to the Federal State Statistics Service, 1,208,600 people (823.4 per 100,000) in the Russian Federation were reported to be on treatment and prevention programmes for alcohol abuse and alcohol-induced psychoses. An acute clinical condition that develops due to the abrupt cessation of alcohol intake or a marked decrease in consumption, is one of the dangerous conditions that occur in patients with alcoholism. This syndrome develops 6 to 24 hours after alcohol withdrawal due to prolonged alcohol consumption. Alcohol withdrawal syndrome is characterised by vegetative and mental disorders, which can be complicated by alcohol delirium, seizures and lead to disability and death [6]. We have not found any published studies investigating the relationship between the severity of alcohol withdrawal and melatonin receptor genes
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