Su2084 Acute Tryptophan Depletion Reduces Kynurenine Levels: Implications for Treatment of Impaired Visuospatial Memory Performance in Irritable Bowel Syndrome

Abstract

Rationale A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine can cross the blood brain barrier and lead to the production of neuroactive metabolites, which modulate glutamatergic and cholinergic signalling, key neurotransmitter systems involved in cognitive function.