Abstract
Novel insights which may translate into treatments for irritable bowel syndrome
Highlights
Irritable bowel syndrome (IBS) is a very common functional disorder of the digestive tract
The bidirectional communication between the brain and the gut opens up new treatment possibility for IBS patients with mood disturbances that are refractory to first-and second-lines therapies
Eberlin et al reviewed the pharmacokinetics, pharmacodynamics and clinical data of racecadotril, a powerful and selective enkephalinase inhibitor, which has emerged as a promising drug in the antisecretory therapy (Eberlin et al, 2012)
Summary
Irritable bowel syndrome (IBS) is a very common functional disorder of the digestive tract. The bidirectional communication between the brain and the gut opens up new treatment possibility for IBS patients with mood disturbances that are refractory to first-and second-lines therapies. Jeremy Gale and Lesley Houghton reviewed the preclinical and clinical data which support the potential use of gabapentin and pregabalin in disorders characterized by visceral hypersensitivity, such as IBS (Gale and Houghton, 2011).
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