Abstract
Wide-spread screening for Barrett's Esophagus (BE) remains elusive because the standard of care, endoscopic biopsy, is expensive, usually requires sedation, and is subject to sampling error. Optical Coherence Tomography (OCT) is an endomicroscopy technology that provides 10μm-resolution cross-sectional images of the gastrointestinal tract. We have developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires microscopic images of the entire esophageal wall. TCE could be a suitable tool for BE screening because it can be rapidly (∼5 min) conducted using an inexpensive, portable device in unsedated patients.
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