Abstract
which can classify the cyst samples. Results: Sixty nine patients who underwent EUS-FNA (median age 66, range 20-90 years, including 32 males) with PCs ranging in size from 780 mm (median 18 mm) were included in the analysis. Median fluid CEA level was 144 ng/ml (range 0.2-392310). Mucinous lesions were diagnosed in 30 and non-mucinous in 39 patients. A total of 101 miRNAs were differentially expressed in mucinous cysts, out of which only 11 have been previously reported in literature to be overexpressed in mucinous PCs and/or pancreas cancer (mi10b, 181a, 212, 26a, 30a, 194, 200c, 200b, 99b, 192, and 31). Out of 101, 36 unique miRNAs were found to be overexpressed based on detectable expression in at least 50% of the lesions aspirated. Table 1 and Figure 1 depict the differential expression in the top group of miRNAs assessed. Conclusion: EUS-FNA is a reliable method for PC fluid acquisition and does not appear to affect the ability to profile miRNAs in the fluid. We report on a larger cohort of miRNAs differentially expressed in mucinous PCs than previously described. Further validation of our findings is warranted.
Published Version
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